The German Commission E approved the use of chasteberry for PMS and chasteberry has the most convincing clinical data of the botanicals for efficacy in treatment of PMS (The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. MA, Boston: Integrative Medicine Communications, 1998). Clinical studies have shown that chasteberry helps alleviate symptoms associated with PMS such as mild mood changes and cramps as well as promote fluid balances and breast health (Schellenberg R. Treatment for the premenstrual syndrome with Agnus castus fruit extract: Prospective, randomized, placebo controlled study. BMJ. 2001;322:134-147.).